4-[4-[(5-nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]-benzoic acid, ethyl ester
418805-02-4
371.3
C17H13N3O7
DMF, DMSO, DMSO:PBS (pH 7.2)
-20°C
PYR41 is a cell-permeable, irreversible ubiquitin-activating enzyme (E1) inhibitor (IC< 10M). Blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-B activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. Also causes an increase in sumoylation of proteins.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
